Joe G N Garcia Selected Research

Nicotinamide Phosphoribosyltransferase

4/2022	Critical role for the lung endothelial nonmuscle myosin light-chain kinase isoform in the severity of inflammatory murine lung injury.
1/2022	eNAMPT Neutralization Preserves Lung Fluid Balance and Reduces Acute Renal Injury in Porcine Sepsis/VILI-Induced Inflammatory Lung Injury.
12/2021	A Humanized Monoclonal Antibody Targeting Extracellular Nicotinamide Phosphoribosyltransferase Prevents Aggressive Prostate Cancer Progression.
1/2021	Endothelial eNAMPT amplifies pre-clinical acute lung injury: efficacy of an eNAMPT-neutralising monoclonal antibody.
1/2021	Cohesive cancer invasion of the biophysical barrier of smooth muscle.
11/2020	Role of secreted extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in prostate cancer progression: Novel biomarker and therapeutic target.
1/2020	Direct Extracellular NAMPT Involvement in Pulmonary Hypertension and Vascular Remodeling. Transcriptional Regulation by SOX and HIF-2α.
1/2017	Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension.
12/2016	Endotoxin- and mechanical stress-induced epigenetic changes in the regulation of the nicotinamide phosphoribosyltransferase promoter.
1/2015	Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia.

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Joe G N Garcia Research Topics

Disease

58	Lung Injury 04/2022 - 11/2003
54	Acute Lung Injury 01/2022 - 05/2003
26	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2022 - 05/2011
25	Sepsis (Septicemia) 01/2022 - 01/2005
25	Inflammation (Inflammations) 01/2021 - 08/2002
22	Ventilator-Induced Lung Injury 04/2022 - 08/2005
21	Hypoxia (Hypoxemia) 12/2021 - 09/2003
19	Asthma (Bronchial Asthma) 01/2022 - 07/2006
19	Neoplasms (Cancer) 01/2021 - 10/2004
17	Pulmonary Hypertension 12/2021 - 09/2003
14	Pneumonia (Pneumonitis) 04/2022 - 01/2008
13	Fibrosis (Cirrhosis) 01/2022 - 02/2013
13	Vascular Remodeling 12/2021 - 09/2003
12	Pulmonary Arterial Hypertension 01/2022 - 11/2014
12	Sarcoidosis (Schaumann Disease) 12/2021 - 08/2010
10	Pulmonary Edema 01/2022 - 04/2003
10	Infections 12/2020 - 07/2003
8	Idiopathic Pulmonary Fibrosis 01/2021 - 04/2013
8	Lung Diseases (Lung Disease) 08/2013 - 02/2005
8	Hyperoxia 04/2012 - 01/2003
7	Sickle Cell Anemia (Hemoglobin S Disease) 01/2022 - 04/2014
6	Critical Illness (Critically Ill) 01/2022 - 11/2006
6	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2016 - 08/2012
5	Familial Primary Pulmonary Hypertension 12/2021 - 01/2016
5	Heart Failure 12/2018 - 11/2004
5	Edema (Dropsy) 01/2016 - 11/2008
4	Wounds and Injuries (Trauma) 01/2022 - 10/2008
4	Prostatic Neoplasms (Prostate Cancer) 12/2021 - 03/2011
4	Pulmonary Sarcoidosis 12/2021 - 04/2014
4	Lung Neoplasms (Lung Cancer) 01/2016 - 09/2009
3	COVID-19 01/2022 - 01/2021
3	Neoplasm Metastasis (Metastasis) 01/2021 - 03/2011
3	Respiratory Insufficiency (Respiratory Failure) 01/2017 - 01/2011
3	Polycythemia (Erythrocytosis) 08/2015 - 09/2003
3	Reperfusion Injury 12/2009 - 11/2003

Drug/Important Bio-Agent (IBA)

42	Proteins (Proteins, Gene)FDA Link 04/2022 - 04/2003
34	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2004
31	CytokinesIBA 04/2022 - 05/2003
21	Myosin-Light-Chain KinaseIBA 04/2022 - 04/2006
19	Nicotinamide PhosphoribosyltransferaseIBA 04/2022 - 02/2005
18	Protein Isoforms (Isoforms)IBA 04/2022 - 06/2003
17	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 03/2017 - 08/2002
15	LipopolysaccharidesIBA 04/2022 - 05/2006
11	Small Interfering RNA (siRNA)IBA 01/2016 - 08/2007
9	Simvastatin (Zocor)FDA LinkGeneric 03/2017 - 09/2003
8	Phosphotransferases (Kinase)IBA 01/2022 - 01/2003
8	Pharmaceutical PreparationsIBA 12/2021 - 06/2008
8	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2019 - 01/2003
7	Transcription Factors (Transcription Factor)IBA 01/2020 - 01/2005
7	Sphingosine-1-Phosphate ReceptorsIBA 12/2018 - 08/2010
7	Tyrosine (L-Tyrosine)FDA Link 04/2018 - 08/2007
6	Interleukin-6 (Interleukin 6)IBA 04/2022 - 05/2006
6	CortactinIBA 01/2022 - 08/2007
6	RNA (Ribonucleic Acid)IBA 12/2021 - 05/2007
6	MonocrotalineIBA 01/2021 - 01/2016
6	MicroRNAs (MicroRNA)IBA 01/2021 - 04/2011
6	Bleomycin (Blenoxane)FDA LinkGeneric 12/2015 - 04/2013
5	AlbuminsIBA 04/2022 - 10/2007
5	Biological ProductsIBA 01/2022 - 01/2004
5	LigandsIBA 01/2022 - 01/2015
5	Therapeutic UsesIBA 01/2020 - 10/2010
5	EnzymesIBA 01/2018 - 07/2006
5	Superoxides (Superoxide)IBA 11/2017 - 01/2003
5	Peptides (Polypeptides)IBA 01/2017 - 08/2007
5	Fingolimod Hydrochloride (FTY720)FDA Link 01/2016 - 01/2013
5	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 03/2012 - 01/2003
5	NADPH Oxidases (NAD(P)H oxidase)IBA 03/2012 - 01/2003
5	DNA (Deoxyribonucleic Acid)IBA 09/2009 - 01/2005
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2022 - 05/2003
4	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2022 - 06/2005
4	Monoclonal AntibodiesIBA 12/2021 - 04/2014
4	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 12/2021 - 07/2003
4	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 01/2021 - 01/2011
4	Toll-Like Receptor 4IBA 01/2018 - 06/2005
4	Messenger RNA (mRNA)IBA 01/2018 - 06/2015
4	Particulate MatterIBA 07/2017 - 11/2008
4	EndotoxinsIBA 01/2017 - 06/2004
4	Hemoglobins (Hemoglobin)IBA 01/2017 - 01/2014
4	SphingolipidsIBA 08/2012 - 08/2002
4	Immunoglobulin E (IgE)IBA 01/2012 - 07/2006
4	p38 Mitogen-Activated Protein KinasesIBA 02/2010 - 01/2003
3	Coloring Agents (Dyes)IBA 04/2022 - 10/2007
3	NF-kappa B (NF-kB)IBA 04/2022 - 06/2005
3	Interleukin-18 (Interleukin 18)IBA 12/2021 - 01/2016
3	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 07/2020 - 02/2008
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 06/2008
3	ChemokinesIBA 12/2019 - 10/2008
3	Organophosphonates (Phosphonates)IBA 01/2016 - 07/2013
3	PaxillinIBA 12/2015 - 01/2013
3	LipidsIBA 08/2015 - 11/2004
3	sphingosine kinaseIBA 11/2014 - 08/2012
3	Thrombin FDA Link 08/2013 - 07/2003
3	Caveolin 1IBA 11/2010 - 04/2009
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2010 - 11/2004

Therapy/Procedure

26	Therapeutics 01/2022 - 11/2004
21	Artificial Respiration (Mechanical Ventilation) 04/2022 - 11/2004
16	Mechanical Ventilators (Ventilator) 01/2021 - 11/2003
3	Ligation 01/2018 - 04/2005
3	Radiotherapy 06/2016 - 03/2011
3	Lung Transplantation 08/2013 - 01/2006